Gelatin/gentamicin sulfate-modified PMMA bone cement with proper mechanical properties and high antibacterial ability

Abstract With the aging of population, risk osteoporotic vertebral compression fractures (OVCF) caused by osteoporosis increases rapidly. Surgeons often fill bone defect with injectable polymethylmethacrylate (PMMA) cement through vertebroplasty. However, compared cancellous bone, higher mechanical properties PMMA can easily lead to fracture adjacent cone. Besides, wound infection surgery is also a serious problem. In order solve these problems, we designed new type cement, adding gelatin as pore former, 5% (w/w) gentamicin sulfate (GS) for antibacterial purpose, and 30% barium (BaSO 4 ) provide excellent radiopacity. Compared traditional dissolution after being immersed in phosphate buffered saline (PBS) 14 d, modified decreased approximately 67%, which close human bone. release GS increased 3.8 times, concentration remained above minimum inhibitory (MIC) 12 d. addition, setting properties, contact angle, ability, cell compatibility maintained well. The integration were observed scanning electron microscope (SEM). All results indicate that gelatin-modified potential candidate material